|
Osteitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The findings suggest that TLR4 has no significant role in the emergence of osteitis after newborn BCG vaccination, but the variant genotypes of the TLR4 rs4986790 and rs4986791 may impair the production of pro-inflammatory cytokines.
|
31755594 |
2019 |
|
Urinary tract infection
|
|
0.040 |
GeneticVariation
|
BEFREE |
Nevertheless, our meta-analysis shows that in Asian populations, TLR4 (rs4986790) may be associated with risk of urinary tract infection.
|
31749314 |
2020 |
|
Recurrent urinary tract infection
|
|
0.020 |
GeneticVariation
|
BEFREE |
Nevertheless, our meta-analysis shows that in Asian populations, TLR4 (rs4986790) may be associated with risk of urinary tract infection.
|
31749314 |
2020 |
|
Gastritis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The relationship between TLR4 rs4986790 and rs4986791 gene polymorphisms and Helicobacter pylori infection in children with gastritis.
|
31690518 |
2019 |
|
Infection caused by Helicobacter pylori
|
|
0.040 |
GeneticVariation
|
BEFREE |
The relationship between TLR4 rs4986790 and rs4986791 gene polymorphisms and Helicobacter pylori infection in children with gastritis.
|
31690518 |
2019 |
|
Infection in children
|
|
0.010 |
GeneticVariation
|
BEFREE |
The objectives of the study were to evaluate the associations between both TLR4 rs4986790 and rs4986791 gene polymorphisms and H. pylori infection in children with gastritis.
|
31690518 |
2019 |
|
Asthma
|
|
0.080 |
GeneticVariation
|
BEFREE |
TLR4 Asp299Gly polymorphisms were associated with asthma and with decreased odds of nonatopic asthma compared with atopic asthma in the adult population in Crimea.
|
31530336 |
2020 |
|
Allergic asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR4 Asp299Gly polymorphisms were associated with asthma and with decreased odds of nonatopic asthma compared with atopic asthma in the adult population in Crimea.
|
31530336 |
2020 |
|
IgE-mediated allergic asthma
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR4 Asp299Gly polymorphisms were associated with asthma and with decreased odds of nonatopic asthma compared with atopic asthma in the adult population in Crimea.
|
31530336 |
2020 |
|
Stomach Carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
Malignant neoplasm of stomach
|
|
0.100 |
GeneticVariation
|
BEFREE |
Nine variants on nine genes were rated as presenting strong cumulative epidemiological evidence for a nominally significant association with GC risk, including <i>APE1</i> (rs1760944), <i>DNMT1</i> (rs16999593), <i>ERCC5</i> (rs751402), <i>GSTT1</i> (null/presence), <i>MDM2</i> (rs2278744), <i>PPARG</i> (rs1801282), <i>TLR4</i> (rs4986790), <i>IL-17F</i> (rs763780), and <i>CASP8</i> (rs3834129).
|
31516756 |
2019 |
|
Cardiovascular Diseases
|
|
0.060 |
GeneticVariation
|
BEFREE |
Three tag single-nucleotide polymorphisms (rs2770150, rs10759931, and rs4986790) in TLR4 were studied on 222 unrelated patients with cardiovascular diseases and 190 healthy volunteers.
|
31328431 |
2019 |
|
Segmental vitiligo
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of Nod-like receptor protein-1 (rs2670660) and Toll-like receptor-4 (rs4986790) with non-segmental vitiligo: A case-control study in South Indian population.
|
31293094 |
2019 |
|
Periodontitis
|
|
0.090 |
GeneticVariation
|
BEFREE |
Thus, the aim of this study was to evaluate the influence of the <i>TLR4</i> A896G (rs4986790), <i>TLR4</i> C1196T (rs4986791), <i>CD14</i> C-260T (rs2569190), <i>RANKL</i> (<i>TNFSF11</i>, rs2277438), and <i>OPG</i> (<i>TNFSF11B</i> C163T, rs3102735) polymorphisms in periodontitis.
|
31281226 |
2019 |
|
Malignant tumor of cervix
|
|
0.030 |
GeneticVariation
|
BEFREE |
CC and CT genotypes of TLR4 rs11536889 and rs1927911 respectively, and TC, CC genotypes of TLR9 rs187084, as well as minor alleles of TLR4 rs4986790 and TLR9 rs187084, were associated with the increased risk of cervical cancer.
|
31278284 |
2019 |
|
Cervix carcinoma
|
|
0.030 |
GeneticVariation
|
BEFREE |
CC and CT genotypes of TLR4 rs11536889 and rs1927911 respectively, and TC, CC genotypes of TLR9 rs187084, as well as minor alleles of TLR4 rs4986790 and TLR9 rs187084, were associated with the increased risk of cervical cancer.
|
31278284 |
2019 |
|
cervical cancer
|
|
0.030 |
GeneticVariation
|
BEFREE |
CC and CT genotypes of TLR4 rs11536889 and rs1927911 respectively, and TC, CC genotypes of TLR9 rs187084, as well as minor alleles of TLR4 rs4986790 and TLR9 rs187084, were associated with the increased risk of cervical cancer.
|
31278284 |
2019 |
|
Urinary tract infection
|
|
0.040 |
GeneticVariation
|
BEFREE |
The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin.
|
31183391 |
2019 |
|
Recurrent urinary tract infection
|
|
0.020 |
GeneticVariation
|
BEFREE |
The Role of TLR4 Asp299Gly and TLR4 Thr399Ile Polymorphisms in the Pathogenesis of Urinary Tract Infections: First Evaluation in Infants and Children of Greek Origin.
|
31183391 |
2019 |
|
Alzheimer's Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
A coding variant in the TLR4 receptor (rs4986790), previously associated with longevity and Alzheimer's disease (AD) risk reduction, was examined in a population isolate (Québec Founder Population [QFP]) and in presymptomatic individuals with a parental history of AD (Pre-Symptomatic Evaluation of Novel or Experimental Treatment for Alzheimer's Disease [PREVENT-AD]).
|
31175027 |
2019 |
|
Guillain-Barre Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, no associations were observed between the genotypes of the Asp299Gly and Thr399Ile SNPs and antecedent <i>C. jejuni</i> infection or disease severity in Bangladeshi patients with GBS.
|
31019995 |
2019 |
|
Hashimoto Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
TLR2 gene Arg677Trp, Arg753Gln, 196-174 del and TLR4 gene Asp299Gly, Thr399Ile polymorphism do not appear to have a role in the development of HT disease.
|
30924423 |
2020 |
|
Glaucoma, Primary Open Angle
|
|
0.030 |
GeneticVariation
|
BEFREE |
Moreover, rs4986790 A/G and rs4986791 C/T showed a stringent association with POAG in allele contrast, heterozygous, recessive, and overdominant models.
|
30877182 |
2019 |
|
Coronary Artery Disease
|
|
0.080 |
GeneticVariation
|
BEFREE |
No association between rs4986790 and CAD risk was found.
|
30784241 |
2019 |
|
Hepatitis C
|
|
0.050 |
GeneticVariation
|
BEFREE |
<i>In silico</i> analysis of rs2149356G allele showed that this mutation is siRNA, which targets the set of genes, especially in the autophagy pathway.<b>Conclusion:</b> We demonstrated that rs4986790 and rs2149356 are associated with HCV infection.
|
30765614 |
2019 |